CHEM 233 Lecture Notes - Lecture 9: Acid Dissociation Constant, Stereochemistry, Grater
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Important: use your molecular models when working on stereochemistry problems! Below is a brief review of ka"s and pka"s, which were extensively covered in chem 121- 123 for a more detailed discussion, please consult the handout on pka"s available in the handouts folder in the connect site. Reminder: the pka of a generic bronsted acid h a is defined as: pka = log ka, where: Reminder: pka"s can be measured experimentally, but they cannot be deduced purely from molecular properties. Estimating the position of a bronsted acid-base equilibrium: the following expression holds true for the acid-base equilibrium between generic bronsted acid ah and bronsted base b : If one expresses keq as a function of the ka"s of ha and hb, one finds that: Conclusion: the position of the equilibrium that is, the keq is given by the ratio of the ka of the reactant acid (a h above) to that of the product acid (b h above)
