FNH 351 Lecture 2: Riboflavin

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31 Jan 2019
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Energy metabolism pathways: succinate dehydrogenase (fad, electron transport chain (fmn + fad, beta oxidation of fa, acyl coa dehydrogenase (fad) Fad to metabolize plp -> pl -> 4pa (fad dependent aldehyde oxidases) Riboflavin supplementation increases plasma [plp] and riboflavin status in adults. Fmn acts as cofactor (w/ b6) to convert homocysteine -> cystathionine. Fad falls off more readily in ppl with mthfr 677tt. Relates to high blood pressure: causes preventable premature death, cardiovascular disease. Hcl + proteases (stomach, pancreas, si) separate riboflavin, fmn, fad non-covalently bound to pro. As free riboflavin (50%), fmn (10%), fad (40%) bound to pro. Uptake into cells: as free riboflavin, converted to fad (5-20%) + fmn (60-95%) Rdas between men and women: body size and energy expenditure. High doses of up to 400mg/day used to treat migraines. Chronic deficiency (ariboflavinosis: cheilosis: inflammation and cracking in corner of mouth, glossitis: inflammation of tongue.

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