MICB 202 Lecture Notes - Lecture 6: Lactoperoxidase, Staphylococcus Epidermidis, Dextran
Document Summary
Topic 3:microbiota of humans, barriers to infection and aspects of innate immunity. The defense protein targets the pg of the cell way. Lysozyme adds water to the o-glycosidic linkages (not peptide chains) and causes osmotic lysis (breaks linkage) Lactoperoxidase catalyzes i- and h2o2 to generate clo- to kill bacteria. Siderocalin keep iron away from pathogen to protect it from infection. There is a net positive charge outside of the outer membrane. camps disrupts the positive charge from mg and ca ions and the negatively charged lps core. They are small peptides and are found everywhere (including stomach). With zn2+ and mild ph makes hole in membrane. There is no single healthy human microbiota: epidermidis found in everybody. Sugar in food taken up by bacteria to make dextran (glycan chain) capsule. Gi tract the large intestine is where most bacteria live. Human body microbiota vary from person to person, but some are overlapped (more prevalent).
