MICB 202 Lecture Notes - Adaptive Immune System, Innate Immune System, Lymph Node
Document Summary
Are made by epithelial and phagocytic cells: stomach acid, lysozyme in saliva, tears (attack peptidoglycan) b. Innate is nonspecific, same proteins recognize the same patterns: changes in bv walls to make it sticky and leaky so fluids, leucocytes (neutrophils, monocytes), complements can enter damanged tissue, monocytes must mature into macrophages before engulfing v. Activated helper t cell tells macrophage how to kill. Identify cellular components and protein components of immune system. Innate: neutrophil: engulf, kill bacteria, macrophage: engulf, kill bacteria. Tissue repair, wound healing: dendritic cell: engulf, kill bacteria/virus. Migrate to lymph node to activate adaptive immune response. Facilitate activation of b cells, ctls, macrophages. Cytokines: ctl: identify body cells that are infected (with virus) or tumor and destroy them, b. Peyer"s patches, tonsils, appendix, adenoids: explain inflammatory response to bacterial pathogen, and cells involved, neutrophils, tlr-4, explain key features of classical, alternative complement pathways, explain key features of innate, adaptive immunity, and how they are connected.
