MICB 202 Lecture Notes - Reverse Transcriptase, Envelope Glycoprotein Gp120, Gp41
Document Summary
2 identical + rna strands nucleocapsid core: fusion and entry change in gp120, virus receptor=cd4 binds to gp120 of virus. Cause conformational: allows gp120 to bind to coreceptor ccr5 or cxcr4, allows gp41 to insert into host membrane and allow fusion. Core is released into cell: reverse transcriptase becomes active in the core while in cytoplasm, core is permeable to dntps, rna +trna primer (cid:0)dsdna (cid:0)nucleus w/ integrase (cid:0)incorproated into genome=latency, using reverse transcriptase. Pol, env: all retroviruses have genome with 3 main parts in same order: gag, gag=structural=capsid, nucleocapsid, matrix, protease, pol: polymerase, integrase, env: gp120 gp41, also some regulatory genes that give virulence, produce more viruses etc, since it is incorporated into cell;s genome, once it is activated, it is treated like any other mrna and processed by giving polya tail and 5" cap by host. =virulent hiv formed: anti virals have many different targets, protease inhibitors, reverse transcriptase inhibitors, ccr5 inhibitors, cxcr4 inhibitors, entry inhibitors etc.
