MICB 202 Lecture Notes - Rna-Dependent Rna Polymerase, Flu Season, Respiratory Tract Infection
Document Summary
Is a orthomyxovirus: enveloped, -rna genome, wide variety of hosts, pleomorphic (many shapes) no true capsid, has envelope, nucleocapsid, genome o, genetic material, 8 separate rna pieces, all (-, each codes for dif gene product. Different variants will determine the virus host range: host range, depends on antireceptor, flu a has subtypes based on hemagglutinin and neuraminidase proteins. 16 ha, 9na: many dif combos are possible, natural host=dabbling ducks benign disease. 2 segments require splicing. mrna for ha and na proteins on er ribosome: complete=made only after accumulation of porteins. Result in new strain that no one is immune too. 2009 swine flu: h1n1 from new combo of genes: from what"s usually found in euro/asia pigs (2) that went into north. North american strain was already a bird, pig, human mix: flu destroys respiratory cells harm the physical barrier, death of these cells results in associated symptoms. Avian flu: classify as low and high pathogenic avian flus.
