MICB 302 Lecture Notes - Memory B Cell, Stromal Cell, B-Cell Receptor

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21 Nov 2012
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Alternative splicing of mrna to make igm/igd abs. Alternative splicing of mrna to make sig instead of mig. B cell activation, diff to form memory b cells and plasma cells: committed t cell progenitor, double positive thymocyte, single positive thymocyte, mature t cell, pro b, pre b, immature b, mature b. Antigen independent phase in bone marrow, fetal liver. B cell activation = secrete ig into body fluids. Synthesis of h and l chains of ig necessary for development. Officially b cell = (h) and l chains expressed on membrane. Development begins in fetal liver, continue bone marrow through life, migrate from outer part of marrow to core during development. Lymphoid progenitor produced by stem cells in outer part of marrow. Immature b (easily killed by recog. of self antigen) until expression of igd on membrane. Mature b moves into the periphery and activated by antigen to become plasma cell or memory b cell.

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