PCTH 201 Lecture Notes - Lecture 21: Drug Interaction, Polypharmacy, Adverse Drug Reaction
25 Nov 2017
School
Department
Course
Professor
Document Summary
It is very difficult to assess the overall clinical importance of many drug interactions. In a hospital study, the rate of adverse drug reactions in patients taking 6-10 drugs was 7%, rising to 40% in those taking 16-20 drugs. Introduction: drug interaction = an interaction between a drug and another substance/condition that alters the pharmacological effect of the drug, drug interactions may. Make a drug less effective (treatment failure) increase the action of a drug (toxicity) cause unexpected side effects: effects of drug interactions are usually unwanted and may be harmful. Types of drug interactions: drug-drug: interaction with another drug (prescription or over-the-counter, drug-nutrient: interaction with food, beverages or supplements, drug-condition: interaction with co-existing medical condition (e. g. kidney/liver disease) A drug/nutrient/condition that alters the pharmacological mechanism and/or the final effect of another drug. A drug/nutrient/condition that alters the absorption, distribution, metabolism and/or excretion of another drug: pharmacodynamic. Suppression of cns activity through increased gaba transmission.
