PHAR 435 Lecture Notes - Lecture 6: Hydroxysteroid, Stereochemistry, Cyp17A1
13 Apr 2017
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Explain what constitutes a steroid = the 4 rings. 1: discuss steroid hormone receptors, describe their functional domains and outline, using a diagram, their mechanism of action. 3: discuss the problems associated with using physiological steroids as drugs and the purpose of chemical modification. Know the general structure, nomenclature, numbering scheme, and stereochemistry of steroids when talking about the steroids. Regulate tissue-specific gene expression exhibit relatively high tissue and ligand selectivity. Exist unbound in the cytosol as receptor complexes. Note: steroid hormones also produce non-genomic effects via alternate pathways! The steroid receptor can be divided into 4 domains, starting from the nh2-terminal. Activates the hres adjacent to the genes that are. The dna binding domain = a short section of amino acids organized into 2 zinc finger motifs. Important for recognition and binding to dna. Also involved in receptor dimerization and receptor translocation into the nucleus. The hinge region = a linker region of amino acids.
