PHAR 435 Lecture Notes - Lecture 10: Androstenedione, Pituitary Gland, Estriol
13 Apr 2017
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Learning objectives: describe by name and location on the steroid molecule the structural features that are necessary for estrogenic activity for. Identify (by name, chemical structure, and location on the steroid molecule) one structural modification that allows estrogens to be active when taken orally. Identify (by name, chemical structure, and location on the steroid molecule) at least one functional group that increases the duration of action of estrogens. Estrogens are the only class of steroid hormones where you don"t need a steroid backbone = serms. Primary sexual characteristics = development and maintenance of the reproductive tract (uterus, vaginal, ovaries) Secondary sexual characteristics = breast development, thinning of the skin. Other: weak anabolic effects in other tissues (bone, muscle, liver, etc. ) Premenopausal women: by granulosa cells in the ovary (remainder is produced in the adrenal cortex) Postmenopausal women: principal source is from peripheral tissues such as adipose tissue. Pregnancy: placenta = major source of estrogen biosynthesis.
