PHAR 441 Lecture Notes - Lecture 6: Piperazine, Hypogonadism, Ulipristal Acetate

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20 Sep 2016
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Serms: recognize g an aromatase inhibitor their mechanisms of action, therapeutic uses and side-effects, explain the actions and uses of the anti-progestin, mifepristone and the selective progesterone receptor modifier, ulipristal acetate. Metabolic product of estrone and estradiol weak estrogenic activity. The menstrual cycle: beginning of cycle: gradual increase in fsh. Initiates follicular growth and development: follicles release estradiol. This first inhibits the secretion of lh and fsh. At the peak of secretion, it causes an lh surge (and to a lesser extent, an fsh surge: in response to the lh surge: Follicular cells decrease estradiol production and begin progesterone production. Corpus luteum forms: corpus luteum produces increased estradiol and progesterone. This inhibits fsh and lh secretion: i(cid:374) the a(cid:271)se(cid:374)(cid:272)e of lh (cid:894)a(cid:374)d if there is(cid:374)"t fertilization): Menstruation occurs: when progesterone and estrogen levels fall: Hypothalamus is released from the negative feedback. Fsh and lh levels slowly rise the cycle repeats. Growth of endometrium during 1st half of the menstrual cycle.

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