PHAR 441 Lecture Notes - Lecture 12: Ablation, Vagus Nerve, Pharmacology
10 Dec 2016
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Document Summary
Antiarrhythmics: appreciate the pathway of cardiac electrical conduction, understand the ionic basis for cardiac action potential and its misbalance during arrhythmias, learn the pharmacology of anti-arrhythmic drugs, understand non pharmacological methods for treating arrhythmia. Deaths from arrhythmias = 55,000 deaths per year in north america ~300,000 worldwide. The heart does(cid:374)"t e(cid:373)pty as (cid:449)ell blood is stagnant in the heart emboli can dislodge and go to the brain = embolic stroke. Also, (cid:271)e(cid:272)ause the (cid:271)lood is stag(cid:374)a(cid:374)t i(cid:374) the heart, it does(cid:374)"t (cid:272)o(cid:373)e i(cid:374) (cid:272)o(cid:374)ta(cid:272)t (cid:449)ith the (cid:374)atural a(cid:374)ti(cid:272)oagula(cid:374)t mechanisms present in the capillaries (protein c is activated in the capillaries) Driving force for the heart to pump blood is the synchrony of cardiac electrical conduction does(cid:374)"t allo(cid:449) (cid:448)e(cid:374)tri(cid:272)les to pu(cid:373)p at the same time as the atria. The av node needs to be delayed (120 msecs) in its firing of the ap so that the (cid:448)e(cid:374)tri(cid:272)les a(cid:374)d atria do(cid:374)"t pu(cid:373)p at the sa(cid:373)e ti(cid:373)e:
