PHAR 430 Lecture Notes - Lecture 10: Hydrophile, Carboxypeptidase A, Captopril
Document Summary
Ace inhibitors: the story of how ace inhibitors were discovered had a curious trajectory from brazilian plantations to a university of london laboratory to merck. We will learn how each step along the way provided insight into the structural scaffolds found in current ace inhibitors. Hypertension elevation of arterial blood pressure above a defined normal value, which differs with sex and age. Blood pressure a fxn of the amount of blood pumped by the heart (cardiac output, co) and the ease with which blood flows through the peripheral vasculature (total peripheral resistance) Most common modifiable risk factor for cv disease. Risk of cv events (mi, stroke, chf, end-stage renal disease) can be greatly reduced by lowering blood pressure by decreasing total peripheral resistance or cardiac output through pharmaceutical intervention. Ppl tried to understand how mammalian body regulates blood pressure. Injected extract made from kidney into rabbits.