PHAR 435 Lecture Notes - Lecture 8: Gestrinone, List Of Androgen Esters, Dihydrotestosterone
13 Apr 2017
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Learning objectives: draw the minimum structure (pharmacophore) necessary for androgenic activity. Identify by name, structure, and location on the molecule, two functional groups that (when added to the minimum structure) increase binding affinity for the androgen receptor. Identify by name, structure, and location on the molecule, two structural modifications that result in an increase in the anabolic activity relative to the androgenic activity. Identify (by name, structure, and location on the molecule) one structural modification that allows androgens to be active when taken orally and explain how the modification produces this effect. Anabolic most effects on muscle and bone -- encourage/stimulate growth (opposite of gcs) Sexual development for males primary development (seminal vesicles, testes, penis) + maintenance of those characteristics after development. Synthesis of sperm in testes (also need estrogen for this) Secondary sexual characteristics: hair growth, thickening of skin, etc. Anabolic effect maintaining and increasing muscle mass.
