PHAR 454 Lecture Notes - Lecture 5: Orthostatic Hypotension, Body Water, Lean Body Mass
23 Mar 2017
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The elderly chronologically defined as > 65 years of age. Agi(cid:374)g is the progressi(cid:448)e a(cid:272)(cid:272)u(cid:373)ulatio(cid:374) of (cid:858)errors(cid:859) at the molecular, cellular and tissue level. Results in loss of functional units within organs. Clinical syndrome = a constellation of signs/symptoms that are caused by various underlying. This disrupts regulatory processes that integrate cells and organ function disease processes. The process of aging results in: multi-organ dysfunction, heart failure, renal failure, hepatic failure, neurodegeneration, arthritis, reduced capacity to maintain homeostasis, decompensation of organs from (cid:858)(cid:374)or(cid:373)al(cid:859) physiologi(cid:272) fu(cid:374)(cid:272)tio(cid:374) o(cid:272)(cid:272)urs (cid:373)ore easily. Examples of common geriatric syndromes: cognitive decline, orthostatic hypotension, urinary incontinence, frailty, falls, constipation. There(cid:859)s a large ra(cid:374)ge of a(cid:271)ilities i(cid:374) the elderly. Some ca(cid:374)(cid:859)t do a(cid:374)ythi(cid:374)g a(cid:374)d so(cid:373)e still li(cid:448)e a(cid:374) a(cid:272)ti(cid:448)e lifestyle. Which patients are at risk of experiencing decline: high risk watch out for them. Decretion secretion of hydrocholiric acid and pepsin. Any decreased absorption that may occur is likely offset by decreased 1st pass metablism.
