PHAR 460 Lecture Notes - Lecture 19: Chronic Venous Insufficiency, Linseed Oil, Low-Density Lipoprotein
10 Dec 2016
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Part one bp, chf, and chronic venous insufficiency. Learning objectives: demonstrate knowledge of the efficacy and safety of the following natural health products: Garlic, fish peptides and hawthorn for hypertension. Coenzyme q10 for heart failure: you will have be able to comment on talking to patients about nhps and keeping up-to-date with the information on nhps. Coq10 = a coenzyme that helps enzymes in the mitochondria. Also (cid:272)alled u(cid:271)i(cid:395)ui(cid:374)o(cid:374)e (cid:271)/(cid:272) it(cid:859)s p(cid:396)ese(cid:374)t i(cid:374) (cid:373)ost (cid:272)ells. E(cid:272)o(cid:373)(cid:373)e(cid:374)ded fo(cid:396) pts (cid:449)ith hf (cid:271)/(cid:272) it(cid:859)s p(cid:396)ese(cid:374)t i(cid:374) high (cid:272)o(cid:374)(cid:272)e(cid:374)t(cid:396)atio(cid:374)s i(cid:374) the hea(cid:396)t. Some evidence that people with lower coq10 have more severe hf. May work as an anti-oxidant, or affect calcium-dependent ion channels in heart muscle. Cochrane 2014 review = insufficient evidence: studies too small, heterogeneous, bias. 2013 ma of 13 rcts = improved ejection fraction 3. 7% Limitations = small study (n=395), short (4-28 weeks), no recent studies (bbs started to be used in.
