PHAR 462 Lecture Notes - Lecture 6: Ibuprofen, Migraine, Analgesic
8 Apr 2017
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Apap 1000 mg vs. placebo for non- incapacitating migraine. 2 hr headache relief in 57. 8% of pts on apap vs. 38. 7% of pts on placebo. Subgroup analysis: apap better for those with severe headache; nss for moderate headache. 2 hr headache-free rates: 22. 4% (apap) vs. 11. 3% (placebo) 2 hr headache relief: 56% (apap) vs. 36% (placebo) nnt = 5. Nausea, photo and phono-phobia also reduced at 2 hours with apap vs. placebo (nnt 7- 2 hr pain-free: 19% (apap) vs. 10% (placebo) nnt = 12: subgroups analysis: apap better for those with severe headache; nss for moderate headache. Ibuprofen 200 mg vs. ibuprofen 400 mg vs. placebo for mild-moderate headache. Ibuprofen 200 mg (41. 7%) vs. ibuprofen 400 mg (40. 8%) vs. placebo (28. 1%) Phono and photo-phobia improved only with 400 mg ibuprofen. Apap 500 mg + asa 500 mg + caffeine 130 mg (aac) is superior to ibuprofen 400 mg (p<0. 03)
