PHAR 471 Lecture Notes - Lecture 1: Collagen, Fibril, Carbonic Anhydrase
14 Sep 2016
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Document Summary
Osteoporosis causes more than 8. 9 mil fractures per year worldwide. 1 in 3 women and 1 in 5 men will suffer from an osteoporotic fracture during their lifetime. Locomotion (site of insertion and support for muscles and joints) Osteocytes: embedded in bone (formed from osteoblasts), they are also the first sensors of micro cracks and signal to. Collagen type 1: good for flexibility and strength. No haversian canal have small little openings instead wehre they get nutrients. Only 15-25% of the trabecular volume is calcified (the remainder being occupied by bone marrow, blood vessels and ct) Mesh-like bone (trabeculae) located in center of bones especially vertebral bones. Structure (with horizontal and vertical cross- struts contribute to it"s strength. Densely packed layers of mineralized collagen with few spaces (80% to 90% of the volume is calcified) B: osteons many osteons make up the bone. C: collagen fibers are lined up to form osteons each layer has a different orientation.
