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Class Notes for Pharmacology and Therapeutics at University of British Columbia

PCTH 201 Lecture Notes - Lecture 23: Testicular Atrophy, Antidoping, Epitestosterone
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Performance-Enhancing Drugs Doping: the administration of or the use by a competing athlete of any substance foreign to the body or of any physiological substance taken in abnormal route of entry into the body, with the...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 22: Corpus Luteum, Combined Oral Contraceptive Pill, Levonorgestrel
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Reproductive Pharmacology Overview Endocrine Reproductive Function Sex Steroids Subclass of steroid hormones - Estrogens (estradiol) - Progesterones - Andr...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 21: Drug Interaction, Polypharmacy, Adverse Drug Reaction
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Drug Interactions Objectives Differentiate the three major types of drug interactions Understand some of the pharmacodynamic and pharmacokinetic mechanisms of drug interactions Apply your knowl...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 20: Bioavailability, Barbiturate, Abciximab
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Where Do Drugs Come From? Objectives Learn the different sources of drugs, including natural and non-natural sources Be familiar with examples of drugs derived from each source Understand some of the h...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 16: Neurotransmission, Bipolar Disorder
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Psychiatric Drugs Objectives Understand the physiology of neurotransmission in the brain Differentiate the different types of psychiatric disorders Identify the different classes of psychiatric drugs, ...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 17: Hypoventilation, Palpitations, Nonbenzodiazepine
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Anxiety Disorders and Anxiolytics Anxiety Disorders Characterized by excessive, exaggerated, irrational fear and dread Include panic disorder, generalized anxiety disorder, and various phobias (social ...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 16: Suicidal Ideation, Headache, Reuptake
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Classification 1. Antidepressants: MAOIs, TCAs, SSRIs, SNRIs 2. Mood stabilizers: lithium, anticonvulsants 3. Antipsychotics: typical, atypical 4. Anxiolytics: BZDs, azapirones Depression and Antidepre...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 17: Polyuria, Hypothyroidism, Bipolar Disorder
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Psychiatric Drugs Bipolar Disorder and Mood Stabilizers Bipolar Disorder Formerly called manic depression Characterized by drastic mood changes alternating between extreme highs (mania) and extreme ...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 19: Antimicrobial Resistance, Multiple Drug Resistance, Methicillin
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Antibiotic Resistance If you use penicillin, use enough. The percentages of both hospital-acquired and community-acquired bacteria resistance to penicillin and methicillin have increasing throughout the years. Antibiot...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 18: Penicillium Chrysogenum, Penicillin Binding Proteins, Phenoxymethylpenicillin
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Antibiotics Terminology Antimicrobials - Antibacterials - Examples: bleach, H O 2 2Cl - Antibiotics Death or suppression of bacterial growth Micro-organism derived (synthetic/semi-syn...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 15: Naltrexone, Apoptosis, Low Birth Weight
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Alcohol In science, a class of compounds. In society, a specific drug. e.g. Ethyl alcohol, or ethanol Fermentation byproduct of yeast + sugar. The consumption of alcohol (in quantity) far exceeds any other drug in so...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 14: Rna Splicing, Gene Polymorphism, Sepsis
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Population variability & Pharmacogenomics 2 Overview Population variability & genomics vs. Pharmacological response - Gene polymorphism - Sepsis: vasopressin/norepinephrine - Sepsis: Xigris - Tumor...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 13: Seasonal Affective Disorder, High-Density Lipoprotein, Light Therapy
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Population variability & Pharmacogenomics Environment Factors Most ubiquitous environmental factor that may affect drug responses? Seasons. I am a silent killer unless severely high. I affect of Earths adult populatio...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 12: Amide, Ondansetron, Coronary Artery Disease
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Postsurgical Patient Management Objectives 1. Understand the risk factors and management of nausea and vomiting after surgery 2. Understand the basic mechanism of action and complications analgesic medications ...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne
PCTH 201 Lecture Notes - Lecture 11: Inhalational Anaesthetic, Local Anesthesia, Hyporeflexia
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Principles of Surgical Anesthesia Objectives 1. Describe the broad types of anesthesia (general, neuraxial and regional) 2. Understand the basic mechanism of action and complications associated with drugs ...

Pharmacology and Therapeutics
PCTH 201
Andrew Horne

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