PHRM 211 Lecture Notes - Lecture 13: Orthostatic Hypotension, Chronic Pain, Nortriptyline

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25 Apr 2020
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10 mg qhs, increase by no more than 10 mg weekly. Maximum dose : 150 mg (often limited by tolerability) Recommended initial : 10-25 mg qhs, increase by 10-25 mg at weekly intervals as needed and as tolerated (usual dose 50-150 mg qhs) 5-10 mg qhs, increase by no more than 10 mg weekly. Maximum dose : 150-200 mg qhs (often limited by tolerability) Adverse effects : dry mouth , sedation , headache, orthostatic hypotension, constipation, ecg changes, weight gain , (gi distress, dermatitis, sexual disturbance) 37. 5 mg daily x 1 week, then increased weekly. Recommended initial : 37. 5-75 mg daily, then increased at > 4 day intervals. Note : < 150 mg daily = ssri , > 150 mg daily = snri. 30 mg daily (or 15 mg compounded cap) x 1 week. More conservative recommendation for frail or somatically focused patients : Anxiety causing clinically significant distress in patients with generalized anxiety disorder (gad)

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