PHRM 211 Lecture Notes - Lecture 13: Postherpetic Neuralgia, Ketoprofen, Diclofenac
Document Summary
Author"s conclusions: in chronic musculoskeletal conditions with assessments over 6 to 12 weeks, topical diclofenac and ketoprofen had limited efficacy in hand and knee osteoarthritis, as did topical high-concentration capsaicin in postherpetic neuralgia. Nnts were higher, this still indicates that a small proportion of people had good pain relief. Except for topical lidocaine and capsaicin 8% , there is little evidence for the efficacy of compounded topical therapies for peripheral nep. Minimal harm (multiple studies showing minimal or negligible systemic absorption) Clinical experience some benefit, especially in crps. Some bases seem to be better than others. Cream bases preferred for adherence issues some are greasy and unpleasant to apply. Some variability in drug delivery and penetration (controversial) Simplified guidelines limit medical cannabinoid in general. Strong recommendation : not recommended for headache or rheumatologic pain. Strong recommendation : recommended against medical cannabinoids as first or second-line therapy in neuropathic pain limited benefits and high risk of harms.
