PHRM 211 Lecture Notes - Lecture 15: Release Liner, Clonidine, Pharmaceutics
Document Summary
Pharmaceutics of patch dosage form (part 2) Major components: protective or release liner (peel strip, adhesive layer, rate controlling drug release membrane, drug reservoir (semi-solid, soft, outer backing. Rate controlling membrane controls the release rate of drug from the reservoir. Drug should permeate the rate controlling membrane and adhesive layer, but not protection of the drug and patient; (c) occlusion of the applied skin the protective liner and the outer backing. Two general designs with regards to the adhesive layer: may be a rim around the drug matrix or, matrix itself may be adhesive. Quiz 2 : in a matrix transdermal system, the drug is included in what component: backing layer, adhesive layer, protective liner, all of the above. Quiz 3 : all of the following factors favor percutaneous absorption of drugs, except: longer time of application, small drug molecular weight, wet skin, a thick layer of stratum corneum. Constant drug delivery providing a more stable plasma concentration without peaks.
