PHRM 311 Lecture Notes - Lecture 14: Osteoporosis, Pharmacodynamics, 5-Ht2A Receptor
Document Summary
Special aspects of pk for the brain (part 2) Extremely variable response to these drugs are hallmarks of the classes. It is now understood that some of the variability is due to transporter expression at the bbb and less entry into the brain. Antipsychotics as an illustrative example of other neuro-pk considerations. Generally classified according to their mechanism of action and se profiles. Antipsychotic action thought to be result of high-affinity d2 receptor antagonism. Examples: clozapine (archetypal drug) and many compounds sharing some of its pharmacological properties. Mainstay of pharmacological treatment in several countries. High affinity d2 and 5-ht2a antagonists activity. In general, the antipsychotic drugs (and most drugs for brain disorders) are small , lipophilic , and enter the brain well by diffusion . Differential effects of antipsychotic drugs with sex and other demographic variables. Women experience more adverse effects more frequently than men for antipsychotics unknown if this was pharmacokinetic or pharmacodynamic in nature.
