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psyc 314 psychoneuroimmunology.doc
psyc 314 psychoneuroimmunology.doc

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University of British Columbia
PSYC 314
Frances Chen

Psyc 314: Psychoneuroimmunology Gregory Miller historical View of immune system: Immune system helps get rid of pathogens (infectous microorganisms) in your body Role in pathogen removal and wound healing (make sure you dont get an infection) Immune system regulates itself and doesn't listen to the rest of the body (functions in completely autonomous fashion) Responds to trauma, antigens, tumors All the immune system attends to is wounds antigens and tumors Regulated by internal signaling molecules Heals wounds and fights infections Does this View Make any Sense (biological or evolutionary sense)? Consider other organ systems in body Do they function autonomously? Ex. the heart: has some of its own internal functions; however, it turns out there are many things that connect your brain to your heart (PNS, CNS). Fear is something that is processed in the brain which activates nerves which cause the heart beat to go up Ex. Brain-Gut connections: anticipatory gastric release in response to seeing food. Butterfly's in your stomach. Rats poo in response to fear Ex. Lungs: when you are afraid your breathing rate goes up Ex. Skin: blush in response to embarrassment Crosstalk: Would you want the brain to talk to the immune system? And how about the immune system to talk with the brain? Yes, brain can talk to immune system: you could more efficiently regulate responses. And you would be able to hold off responding to things right away. The brain can offer to the immune system timing: you want the brain to talk to the immune system (if you see someone who is sick you could amp up the immune system). The brain can respond to the environment and prepare the immune system Yes: Immune system should be able to communicate that it needs some parts of the body to be activated to the brain. If you are sick you want to sleep, remove yourself from social situations, spike a fever, reduce apitite.All of those things start from the hypothalamus. Immune system causes cytokines to move to the lymbic system to induce these responses Your immune system, or parts of it, are activated during fight or flight while other parts are shut down PNI Background: Conditioned stimulus is saccharine-flavoured water given to rats UCS is cyclophosphamide inhibits cell growth and slow down immune response After pairing rats are injected with red blood cells from sheep Immune response is them measured by counting the antibodies which are produced Nonconditioned group and placebo groups have large immune response Conditioning procedure of varying levels: immune response is half way from when you give them cyclophosphamide alone and when you do not give them sugar water. Then when given the sugar water alone the immune system stays at the half way point between the placebo and the cyclophosphamide. The rats had the response as if they were given cycloph
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