Psyc 314: Psychoneuroimmunology
historical View of immune system:
Immune system helps get rid of pathogens (infectous microorganisms) in your body
Role in pathogen removal and wound healing (make sure you dont get an infection)
Immune system regulates itself and doesn't listen to the rest of the body (functions in
completely autonomous fashion)
Responds to trauma, antigens, tumors
All the immune system attends to is wounds antigens and tumors
Regulated by internal signaling molecules
Heals wounds and fights infections
Does this View Make any Sense (biological or evolutionary sense)?
Consider other organ systems in body
Do they function autonomously?
Ex. the heart: has some of its own internal functions; however, it turns out there are
many things that connect your brain to your heart (PNS, CNS). Fear is something that is
processed in the brain which activates nerves which cause the heart beat to go up
Ex. Brain-Gut connections: anticipatory gastric release in response to seeing food.
Butterfly's in your stomach. Rats poo in response to fear
Ex. Lungs: when you are afraid your breathing rate goes up
Ex. Skin: blush in response to embarrassment
Would you want the brain to talk to the immune system?
And how about the immune system to talk with the brain?
Yes, brain can talk to immune system: you could more efficiently regulate responses.
And you would be able to hold off responding to things right away. The brain can offer
to the immune system timing: you want the brain to talk to the immune system (if you
see someone who is sick you could amp up the immune system). The brain can respond
to the environment and prepare the immune system
Yes: Immune system should be able to communicate that it needs some parts of the
body to be activated to the brain. If you are sick you want to sleep, remove yourself
from social situations, spike a fever, reduce apitite.All of those things start from the
hypothalamus. Immune system causes cytokines to move to the lymbic system to induce
these responses Your immune system, or parts of it, are activated during fight or flight while other parts
are shut down
Conditioned stimulus is saccharine-flavoured water given to rats
UCS is cyclophosphamide inhibits cell growth and slow down immune response
After pairing rats are injected with red blood cells from sheep
Immune response is them measured by counting the antibodies which are produced
Nonconditioned group and placebo groups have large immune response
Conditioning procedure of varying levels: immune response is half way from when you
give them cyclophosphamide alone and when you do not give them sugar water. Then
when given the sugar water alone the immune system stays at the half way point
between the placebo and the cyclophosphamide. The rats had the response as if they
were given cycloph