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menstrual cycles

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BIL 116

Menstrual Cycle Follicular stage [days 1-13]  Pituitary gland secretes follicle-stimulating hormone (FSH)  FSH travels in blood to ovary  Stimulates development (division) of follicle cells surrounding the oocyte  Developing follicle cells secrete oestrogen o Stimulates proliferation of endometrium and its blood supply o Inhibits further secretion of FSH by negative feedback o Stimulates pituitary gland to secrete luteinising hormone (LH)  LH causes ovulation Ovulation [day 14]  Mature ovarian follicle bursts and releases a 2° oocyte (NOT an ovum) o Happens once a month, menstrual cycle ≈28days o Each ovary alternatively releases a 2° oocyte every ≈56days (→56/2)  LH forms the corpus luteum from ruptured follicle Luteal phase [days 15-28]  Corpus luteum secretes progesterone  Progesterone is responsible for o Proliferation of endometrium and its blood supply o Development of nutrient fluid glands in uterus lining o Inhibition of LSH and LH  Corpus luteum degenerates (due to inhibition of LH) Menstruation [days 1-5]  Also called menses, period, menstrual bleeding  Sign that not pregnant  Shedding of the endometrium due to low levels of progesterone and oestrogen  FSH is not inhibited anymore → cycle starts aga
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