MDST*2020 Lecture Notes - Lecture 4: Unkle, Wild Type, Dont
Document Summary
This structure is unstable and if it happens any times you can destroy protein. But huntington can tolerate this to a certain extent. 12. use taq polymerase- don"t care about errors just want quick readin. Must know this slide you will get a digram of this and you have to be able to tell about each patrent and weather they will get huningtons disease or not exam question identify hd person. 19 don"t know picture but need to know points. Take this gene and cleave it, if 2 small fragments = wild type healthy. 1 is not intergrated into genome and generates immune response. Problem is where this intergratd piece of dna will go, this gene will change genes around it. So integration site now the problem not the immune system. The vector was integrated next to unkle gene. 49 john and jim have different number of repeats. 50 this is called a restriction fragment length polymorphism.
