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BIOL 1010U (101)
Ani (35)
Lecture

B CELL DEVELOPMENT

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School
Department
Biology
Course
BIOL 1010U
Professor
Ani
Semester
Fall

Description
B CELL DEVELOPMENT, HUMORAL IMMUNE RESPONSE, TOLERANCE PHASES OF B CELL DEVELOPMENT – prenatal – in liver postnatal – bone marrow from hematopoetic stem cells ANTIGEN INDEPENDENT: occurs in bone marrow Allelic exclusion – only one allele is expressed  higher specificity a result of ORDERED GENE REARRANGEMENT 1. CLP – Common Lymphoid Progenitor 2. ProB – DJ rearr. (HC) stim by B220 (cell surface antigen) occurs on BOTH alleles 2/3 of rearrangement result in loss of reading frame 3. PreB – VDJ rearr. (full HC, but no LC) occurs more slowly only 2 tries to get in frame (maternal and paternal alleles) if unsuccessful  cell dies if successful  pre-B cell receptor (PreBCR) exposed **PreBCR exposure: principal checkpoint** - stops heavy chain rearrangement (AE) - starts light chain rearrangement - blocks apoptosis - proliferates Detecting B Cell Developmental State: anti B220 stains for B cell lineage anti CD43 stains for maturation CD43 anchors ProB cells to marrow no CD43, but B220 present  PreB cell RAG2 deficient  CD43+, B220+
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