BIOL 1010U Lecture Notes - Phospholipid, Anaphylaxis, Complement Component 5A

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30 Jan 2013
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Allergen = antibody that elicits an ige (reagin) response. Small proteins or chemicals bound to proteins. They display sensitization (previous exposure elicits a reaction) Ri high affinity binding (mast cells, basophils) tetramer (abg2); beta and gamma domains have itam motifs trimeric version (no beta) found in monocytes and dc"s. Rii low affinity binding; also called cd23. 2 signals work on b cells: il4/il13 from th2 cells, basophils, and mast cells. **activates e gene transcription** occurs via jak/stat6 pathway: cd40/cd40l binding between b and th2 cells. Crosslinking by allergen causes degranulation, tyrosine kinase activity. Early phase (minutes) skin (wheal, flare, itchiness) airway (sneezing) mediated by histamine/heparin degranulation leukotriene/prostaglandin synthesis from memrane lipids. Late phase (hours) recurrent airway/skin problems mediated by cytokines/chemokines (il4/il13) expression and secretion involves other cells" migration (eosinophils, basophils, lymphocytes) Granule products (heparin, histamine, tryptase) histamine"s effects: nerve activation (for sneezing/pruritis) vasodilation (tissue swelling/hypotension) gland secretion (musocal) smooth muscle contraction (bronchocontriction, diarrhea)

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