BIOL 1010U Lecture Notes - Signal Transduction, Superoxide, White Blood Cell

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30 Jan 2013
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Innate immunity: definition, activation, receptors: innate versus adaptive immunity. Activation of innate immune response: pamps and prrs. General invariant features of pathogen surfaces are recognized (pathogen assoc. Molecular patterns, pamps) by a limited set of fixed receptors (pattern. Tlrs are prrs, originally discovered as dtoll and 18-wheeler in drosophila. In humans, 9 types of tlrs recognize pamps and activate innate immune. There are 3 effector cells of the innate immune system: neutrophils: short lived phagocytes, kill, macrophages: long lived phagocytes, kill, involved in inflammation, remodeling, natural killer (nk): kill viral infected cells that lack mhc i. Metchnikoff first observed phagocytic cells in late 1800"s: differentation of neutrophils and macrophages, pluripotent hematopoietic stem cell gives rise to: 1) neurons, 2) endothelium, erythroids, 4) megakaryocytes, 5) myeloids, 6) lymphoids, neutrophils. Increased immature neutrophils in circulation is sign of. , g-csf, gm-csf) stimulate neutrophil production infection/inflammation: macrophages.

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