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BIOL 1010U (101)
Ani (35)
Lecture

IMMUNOLOGY T CELL

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School
Department
Biology
Course
BIOL 1010U
Professor
Ani
Semester
Fall

Description
IMMUNOLOGYT CELL SELECTION AND CENTRAL TOLERANCETolerancestate of the immune system characterized by unresponsiveness to a particular antigen ability to distinguish self from non selfunique and important to ISFREEMARTIN condition in twin cattleBURNET hypothesis dizygotic twins sharing a placenta will therefore share RBCs hematopoitic chimera share stem cellsdevelopingimmature lymphocytes are subject to CLONAL DELETION in presence if selfantigens are recognizedCLONAL DELETION MODELself tolerance learned by developing immune system occurs during fetal and neonatal developmenttolerance decreases rapidlyif exposed to antigen in embryotolerancein adultrejectionIf receptor of immature lymphocyte engages a selfantigendeletion of that cloneTCELLSmore important than Bcells for toleranceCentral Tolerancegenerated during lymphocyte development involves clonal deletionPeripheral Tolerancegenerated AFTER lymphocytes have matured involves ANERGY inactivationT CELL DEVELOPMENT occurs in thymus in 3 stages1 TCR gene rearrangements result
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