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Lecture

Control of ECF Volume I—Guggino

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School
Department
Biology
Course
BIOL 1840U
Professor
Peter Cheung
Semester
Fall

Description
Control of ECF Volume I—Guggino I. Conserving and balancing body H2O a. Humans can excrete large or small quantities of water independently of solutes b. Kidneys regulate water excretion over large range! c. Sensing changes in Osmolality i. Osmoreceptors—located in circumventricular organs in brain; contain non-selective Ca channels 1. regulate thirst & secretion of ADH 2. only respond to changes in effective osmolality (ie if a freely permeable solute is responsible for the change in osmolality, osmoreceptors won’t notice) ii. Thirst 1. also very sensitive to changes in plasma osmolality, but can also be stimulated by changes in bl. volume/pressure 2. Factors controlling
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