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Lecture

Overview of Renal System

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School
Department
Biology
Course
BIOL 1840U
Professor
Peter Cheung
Semester
Fall

Description
Outline of Lecture 01 (04-24 B; Guggino) Overview of Renal System I. Functions of the human kidney - Main function: maintain volume and solute concentration in extracellular fluid - Also, excrete substances, make glucose, NH , a3d hormones II. Control of fluid compartments - Fluid is compartmentalized in the human body - Intracellular fluid: holds about 2/3 of body fluid - Extracellular fluid: holds about 1/3 of body fluid - Divided into interstitial, intravascular, and transcellular fluids - Water is freely exchangeable among all body compartments, but distribution is controlled: - By solute concentration (a colligative property), and - By hydrostatic pressure - Solute distribution is controlled - By permeability - By transporters - For ions, by ion pumps (a transporter) and membrane potential - Intracellular volume is controlled by each cell by regulating solute concentration - e.g. by regulating Na and K concentration via the Na/K pump - Extracellular volume and solute concentration is
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