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T-Lymphocytes: Cell-Mediated Response

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BIOL 2020U

T-Lymphocytes: Cell-Mediated Response  Virus enter cell and more difficult to remove  No antibodies involved / work directly on the infected cell by destroying it  Special proteins called Major Histocompability Complex (MHC) are present on all human cells  Non-self antigen interacts with MHC as human cell becomes infected by a pathogen  Specific T-lymphocyte recognises specific non-self antigen only with a chemical marker next to it (MHC)  Activated T-lymphocytes multiply by mitosis and enter circulation  Cells differentiate into different types of cell o Cytotoxic T-Cells destroy pathogens and infected cells by enzyme action, and secrete chemicals which attract and stimulate phagocytes o Helper T-Cells stimulate the activity of the cytotoxic T-Cells and B-lymphocytes by releasing chemicals (cytokines andinterleukins). Destroyed by HIV o Suppressor T-Cells switch off the T and B cell responses when infection clears o Memory T-Cells Some activated T-Cells remain in the circulation and can respond quickly when same pathogen enters body again IMG 3-12-3 Table 3-12-3: Different types of immunity Passive (Given- Active (Antibodies made Antibodies, short term by the human immune acting) system, long term acting due to memory cells) Natural - Response to disease - Acquired antibodies - Rejecting trans
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