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Lecture 11

Outline of Lecture 11

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School
Department
Biology
Course
BIOL 2050U
Professor
Peter Cheung
Semester
Fall

Description
Outline of Lecture 11 T Cell Selection and Central Tolerance I. Tolerance defined A) Freemartin cows indicate that self tolerance is learned by developing immune system B) Neonatal tolerance experiment confirm Burnet hypothesis C) Two types of tolerance 1) Central tolerance: learned during lymphocyte development (clonal deletion) 2) Peripheral tolerance: in mature lymphocytes, multiple mechanisms (typically results in anergy) CENTRAL TOLERANCE II. Step 1: TCR gene rearrangement 1) T cell starts out CD4- CD8-, migrates from bone marrow to thymus 2) TCR γ (VJ), δ (VDJ) rearrange (small subset of cells stop here) 3) TCR β VDJ rearranges, β is expressed with preTCRα(surrogate αchain, lik
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