BIOL 2050U Lecture Notes - Interleukin 4, Zygosity, Interleukin 2
Document Summary
Natural killer cells part of innate immunity; no prior exposure is necessary anti viral, anti-tumor, transplant rejection, materno-fetal interaction roles protection during t-cell priming period from cd34+ precursors; il15-driven maturation in bone marrow. Nk cells recognition: antibody (igg, adhesion, non-mhci expressing cells. **nk cells are unique in that they will lyse donor cells not expressing. Mhc recognition inhibits lysis no activation necessary (by cytokines for example) can release inflammatory cytokines (ifn-g, tnf-b, gm-csf) th1 act. anti-tumor roles perforin-lysis no antigen recognition. Nk receptors inhibitory contain itim"s that have downstream phosphatase activity to inhibit intracellular signaling. Kir"s immunoglobin like; can bind mhci multiple types expressed per cell more recognition. Cd94/nkg2 binds to hla-e tetramers (non-classical mhc molecules) Hla-e binds to mhci signal sequences cleaved in the er activating receptors associate noncovalently with itam containing molecules. Nkg-2d: ligands are mica, micb (mhc homologs that are. Dap10 contains itam upregulated in stressed cells) both are coexpressed and inhibitory signals usually dominate over activating.
