CHEM 4510U Lecture Notes - Lecture 1: Clinical Trial, Enantiomer, Suzuki Reaction

• School: UOIT
• Department: Chemistry
• Course: CHEM 4510U
• Professor: yuri bolshan

Document Summary

6:15 pm pharm discovery page 1 pharm discovery page 2. Ld50 is the dose that will kill 50% of the population. He discovered zinc and named it, zinc means pointy in german pharm discovery page 3. Louis xiv was cured by antimony and it was reestablished in french parliament. Suggested the general term alkaloid, contains nitrogen gas law. Published a detailed procedure for extracting and purifying morphine. This is natural product isolation not medicinal chemistry. The ability to stabilize the negative charge on the anion, will say if it is a good leaving group. Stabilization of a charge is similar to standing on the ice, if you stand or lay down. A large element can distribute the charge over a larger area, depolarization. Sn1 , get an intermediate (first the leaving group would leave then the nucleophile will attack. Look at other agents and try to functionalize them. Use an electrophile and try to convert it to a salt.