HLSC 2110U Lecture Notes - Lecture 6: Glycerol Kinase, Lactic Acid, Cori Cycle
Document Summary
Very important in kids all over the world during short term starvation since they do not store as much glycogen in their liver. Also important in homeless people and people experiencing food insecurity. Sources are lactic acid, glycerol, amino acids (specifically alanine, glutamine, aspartic acid) Normal concentration in the blood is about 1 mmol/l. Various tissues produce it and release it into the blood. It is taken from the blood to the liver to by converted to glucose. Glycerol is released continuously into the blood. From the blood it is taken up by the liver and converted to glucose. In the liver glycerol is phosphorylated to produce glycerol 3-phosphate, catalyzed by glycerol kinase. Glycerol + atp glycerol 3-phosphate + adp. Glucose as a signal has an acute effect. Hormones have long term effects achieved by enzyme phosphorylation or by changes in concentration of enzymes. Gluconeogenesis is inhibited by insulin but stimulated by the other 3.