HLSC 2400U Lecture Notes - Lecture 6: Myasthenia Gravis, Axoplasmic Transport, Medial Longitudinal Fissure

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21 Jun 2018
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Midterm will cover some tutorial stuff – look over those and review
Midterm in 2 weeks
Some labeling – something that is … only things we talked about
Lecture 1 – levels of neuroscience (start smaller and build on it) – difference between
periphery and central NS
Lecture 2 – know how everything is put together – nerves in what direction of flow –
represent afferent or efferent (info in or out) – movement through contraction of joints
and muscles – in controlled way
Know bolded things on the diagrams of spinal cord (dorsal root) – white and grey matter
- tracts that we’ve talked about – cerebrum – define what it is, know the big landmarks
(longitudinal fissure, central sulcus – know what its important) – different lobes and
what they are (label on the surface of the brain), difference between different motor
areas – know what they are and the difference between them. Maybe label, primary
sensorimotor area, tracts of the white matter (will go right to left, or left to right, go
within same side, or leave and come in to brain), function of basal ganglia, cerebellum,
brain stem (3 areas - know what they are
Lecture 3 – point of neurological system – through electricity (membrane channels –
and neurons), specialized in sense of function, mitochondria, dendrites, presynaptic
terms (output-connection to neuron via synapse), axoplasmic transport (all stuff created
have to be produced in cell body and sent to down pre terms, types of neurons (bipolar,
multipolar – more than 1 or 2 extensions), summation of local/action potentials,
membrane channels (4 kinds - know difference and what they are used for), will open
from modality or from sensation – dendrites of motor neurons, LOOK AT TUTORIAL
NOTES, speed of myelin, electrical potentials (know the numbers for each), summation,
absolute and refractory period difference, different types of non-neural cells, astrocytes,
microglia, autoimmune disorders (myasthenia gravis)
Lecture 4 – synapse, know different steps of synaptic transmission, local potentials
(excitatory or inhibitory about cell membrane), postsynaptic potentials, different
synaptic potentials, difference of axoaxonic and axosomatic, spatial or temporal
summation (voltage channel will fire or not fire - processing info), neurotransmitters and
neuromodulators – know difference and where each is released, effect of binding NTMs
– fast or slow/direct or indirect activation, specific NTMs and receptors – no specifics
about the different drugs – just know some are antagonists or agonists,
Lecture 5 – know the different pathways of the cerebellum, sensory from beginning to
end – processing electrical potential, brain then perceives it from environment
(somatosensation), cells will bind to specific receptors, receptive field (know concept
either big or small amount of area), discriminative touch, cutaneous innervation
EXAM IS NON-CUMULATIVE
Proprioception – muscle spindles, alpha-gama co-activation
Different pathways (conscious – dorsal, anterolateral)
Don’t forget about the face
Receptor to spinal cord, spinal cord to medulla, thalamus to somatosensory
Pain, temp and crude touch, spinothalamic tract – white matter of spinal cord
Fast vs slow (autonomic response that comes from shock) pain
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Document Summary

Midterm will cover some tutorial stuff look over those and review, midterm in 2 weeks. Some labeling something that is only things we talked about. Lecture 1 levels of neuroscience (start smaller and build on it) difference between periphery and central ns. Lecture 2 know how everything is put together nerves in what direction of flow represent afferent or efferent (info in or out) movement through contraction of joints and muscles in controlled way. Know bolded things on the diagrams of spinal cord (dorsal root) white and grey matter. Notes, speed of myelin, electrical potentials (know the numbers for each), summation, absolute and refractory period difference, different types of non-neural cells, astrocytes, microglia, autoimmune disorders (myasthenia gravis) Fast or slow/direct or indirect activation, specific ntms and receptors no specifics about the different drugs just know some are antagonists or agonists, Proprioception muscle spindles, alpha-gama co-activation: different pathways (conscious dorsal, anterolateral, don"t forget about the face.

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