Class Notes (806,814)
Canada (492,451)
UOIT (1,636)

cardio two disorders summary.docx

3 Pages
Unlock Document

Health Science
HLSC 2461U
Otto Sanchez

Cardiovascular Disorders Two Alterations of the Heart Coronary Artery Disease (CAD)  atherosclerosis in the coronary arteries Anatomy of the Coronary Arteries  there are two coronary artieres ( R & L ), both start in the ascending aorta  L coronary artery is most important because it provides the blood supply to most of the L ventricle including the free wall of the L ventricle as well as the septum  L coronary artery divides into Circumflex artery (goes around the back of the heart to meet with the R coronary artery) and L anterior descending artery (travels down the pericardium and send branches into the septum and provide all of the blood supply to the septum)  when obstruction happens in CAD (atherosclerosis in any of these branches) * main L coronary artery: affect blood supply to ALL branches * L anterior descending artery: septum affected Common Obstructions  subendocardial  L anterior descending artery obstruction: affect the septum or part of L ventricular wall  L circumflex artery: affect only the free wall of the L ventricle  when ischemia happens, subendocardium is affected first Risk Factors for CAD  similar to atherosclerosis  non-modifiable & modifiable Modifiable: smoking, chronic arterial hypertension, diabetes mellitus Non-modifiable: male, age, black/Asian Lipoproteins  eat fatintestineliverhepatocyteswhat to doassemble as lipoproteinsblood streamfoam cells??  in the bloodstream: LDL, have receptors in the subendothelial of blood vessels, high % of cholesterol Stable Angina  fibrous plaque without symptoms, stable & fixed  partial obstruction of the flow, shows up whenever there’s ischemia in the heart  pain, SOB, crushing Acute Coronary Syndrome  UA; unstable plaque  STEMI, NSTEMI; thrombus  first lose the ability to electrically function well (shows up on ECG) ** damage always happens in the subendothelium first ** transmural infartct is when all of the walls are affected: subpericardium, subendocardial, myocardium, can form aneurysm Complications Following a Coronary Obstruction  L coronary artery obstruction, in seconds all the myocardial cells affected would become ischemia  changes in the ECG appear  in minutes, myocardial cells can’t contract  anaerobic glycolysis = lactic acid = PAIN!  20-30 minutes cell death happens which is infarction!  18 hours – inflammatory response (autopsy)  precordial pain or referred pain is common (shoulders & jaw) Electrical Changes in the Heart (ECG) P: atrial repolarization QRS Complex: depolarization of the ventricles (AP starts here) T: repolarization of the ventricles * most common alteration is the ST segment in ischemia (ST segment elevation) * common obstruction is the left circumflex artery Post MI Complications 1. Necrosis in the papillary muscles: valvular
More Less

Related notes for HLSC 2461U

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.