HLSC 2463U Lecture Notes - Lecture 10: Basement Membrane, Mellitus, Ketoacidosis
Document Summary
Urine would be a sweet taste in diabetes mellitus. Dm dysfunction with insulin or recognition by its receptor. Di adh production or adh recognition. Receptors for insulin don"t recognize insulin, doesn"t bind. Type 1 pancreas produces much less insulin. Peripheral tissue in muscle that need insulin for glucose to go in. Beta cells produce insulin glut-2 in beta cells that allows glucose to go in, amount of glucose going in is proportional to amount of glucose in the blood, Travel to cells with insulin receptors skeletal muscle, ends with the insertion of another glut-4 transporter into the cell membrane and glut-4 allows glucose to go in and the cell uses it for energy. Glucose binds to receptors, insulin released, binds to receptor. Type 1 beta cells are destroyed, no beta cells, no insulin release at all. The glucose will float around in circulation, cause hyperglycaemia.
