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Lecture

Cellular Physiology of Nerve and Muscle.doc

8 Pages
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Department
Anatomy and Physiology
Course Code
ANP1105
Professor
Jacqueline Carnegie

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Description
Cellular Physiology of Nerve and Muscle The Plasma Membrane pg 6377 flexible defines the extent of the cell and separates the intracellular fluid from the extracellular fluid interstitial fluid synonymous with cell membrane fluid mosaic model depicts the plasma membrane as a thin structure composed of a bilayer of lipid molecules with protein molecules dispersed in it it is fluid because it is constantly changing its shape and patterit is a mosaic because it contains different proteins lipid molecules etc the lipid bilayer is constructed of phospholipids with small amounts of cholesterol and glycolipidseach phospholipid molecule has a polar head that is charged and is hydrophilic waterloving and an uncharged non polar tail that is made of two fatty acid chains and is hydrophobic waterfearing2 fatty acids attached to glycerol and phosphate group on the 3rd position the polar heads attach to water which is the main component of inter and extracellular fluidsthe non polar tails avoid water and line up in the centre of the membrane the plasma membrane is dynamic and in constant fluxit has a consistency like olive oil which allows for lateral diffusion of proteins the inwardfacing and outwardfacing surfaces of the plasma membrane differ in the kinds and amounts of lipids they contain and these variations are important in determining local membrane structure and function membrane phospholipids are mostly unsaturated causing kinks in their tails and increasing space between phospholipids to increase membrane fluidity Glycolipidslipids with attached sugar groupsare found on the outer plasma membrane surface and account for 5 of the total membrane lipidtheir sugar groups make the end of the glycolipid molecule polar fatty acid tails are non polar20 of membrane lipid is cholesterolcholesterol has a polar region hydroxyl group and a nonpolar region ring system it wedges its hydrocarbon rings between phospholipid tails to stabilize the membrane increase mobility of the phospholipid and the fluidity of the membrane
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