APA 2312 Lecture Notes - Lecture 5: Skeletal Muscle, Endoplasmic Reticulum, University Of Manchester
4 Apr 2016
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Document Summary
Ach ataches to sarcolemma (post-synapic membrane) and opens up sodium channels. It"s broken up by ach-asterase into acetyl and choline. Prolonged muscle contracion will occur, if ach is not broken down. Botulism is a toxin that is taken up in the axon. It interferes with an enzyme involved in fusion of vesicles to membrane. Prevents ach vesicles fusing with membrane, and releasing contents to the synapse. A local anestheic has the most efect on type c ibers (small diameter) One a-motor neuron innervates many muscle ibers, collecively called the motor unit. The acion potenial arrives at the dendrites and travels down the axon to the axon terminal. Many poles, high density a-ach receptors communicate with muscle ibers. Where the a motor neuron communicates with muscle ibers. Axon terminal releases neurotransmiters which travel across a synapic clet and bind to receptors on muscle iber"s sarcolemma. Neurotransmiter binding causes depolarizaion, and once a threshold is reached, an ap occurs.
