BCH 2333 Lecture Notes - Lecture 14: Lysosome, Enamine, Pyrimidine Metabolism

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Mm parameters give relaive energies of s+e,e-s, and ts o o o. At vmax, enzyme is saturated with substrate (plateaus) Substrate that transfers an h to nadp+ cofactor. Need to be close in proximity so need ight binding ainiies. Need to collide into each other at the right order and orientaion: h- from thf to the h+ of nadp+ o. Binding ainiies can"t be too great because then the products will not leave the enzyme. Can perform an acid and base catalysis at the same ime with enzymes o o o o. Very powerful mechanism not present in soluion chemistry. Invering mechanism for an glycosidase ec3. In soluion you could not use acid & base at the same ime. Amino acids that paricipate in acid-base catalysis: o o o. Arginine is least likely since its pka is so high. A terminal carboxylic acid is also involved in this catalysis. Zn2+ coordinates carbonyl group and water zinc likes to coordinate oxygen.

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