BIO 1140 Lecture Notes - Lecture 10: Nematode, Necrosis, Mitochondrion
8 Nov 2016
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Mechanisms to kill cells & mechanisms to stop growth. Cell cycle checkpoints (proteins check that cell is healthy, no damaged dna, opportunity to repair/destroy) During development , same number (131) and same exact cells die (same location) Can identify the genes (ced-3) that make proteins responsible for the death of the specific cells. When cell bursts - everything gets released -consequences to neighbour cells. Breaks apart from the inside into small compartments. The compartments - don"t damage neighbouring cells since nothing gets released, everything is kept inside the cell membrane. Cell swelling : taking in ions (calcium), water, membrane is permeable. Intracellular concentration of calcium begins to rise = more stress. All this excess calcium - calpain (protease) becomes active, it targets lysosome membrane, destroying the lysosome membrane. Emptied enzymes : conditions in cell are now favourable for these enzymes to work. Cell starts to swell, ruptures , releasing all its content, including the digestive enzymes, towards the neighbouring cells.
