BIO 1140 Lecture Notes - Lecture 6: Caffeine, Cell Surface Receptor, Integral Membrane Protein

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Topic 6 Signal Transduction
Kristen Batten, 8616820
Monday, February 13th, 2017
- Conserved mechanisms essential for:
o Development
o Immunity
o Physiology
o Hormonal regulation and homeostasis
o Cell growth, survival, cancer
- Cell Communication:
o Focuses on how a cell gives and receives messages with its environment and
with itself. Cells can communicate directly with each other and change their own
internal workings in response.
- Neural activity involves transmission of information via electrochemical events; in
contrast, endocrine activity involves transmission of information via hormone transport
to target tissues
- Indirect Cell Communication Paths:
o Autocrine Regulation: diffusion through extracellular fluid
o Paracrine Regulation: diffusion through extracellular fluid
o Classical Endocrine Regulation: transported in blood
o Neurocrine Regulation: transported in blood
o Classical Neural Regulation: diffuses across synapse
- The target tissues for steroids do not have receptors for them on the membrane
surface, because steroids are soluble in the lipid bilayer.
- 1. Chemical Messengers 6 Classes
o Their structure will determine;
Their chemical properties (hydrophobic vs. hydrophilic)
The communication path taken to reach target cell
Their mode of action / interaction with the cell and receptors
o 6 classes:
steroids
lipids
peptides/proteins
purines
amines
gases
o Steroids:
Derived from cholesterol
Lipophilic cannot be stored in vesicles (endocrine path)
Will diffuse OR be bound to transport protein (i.e. albumin)
Membrane permeable can reach intracellular receptors
Act as gene transcription factors
3 classes of steroids:
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Document Summary

Immunity: physiology, hormonal regulation and homeostasis, cell growth, survival, cancer. Cell communication: focuses on how a cell gives and receives messages with its environment and with itself. Cells can communicate directly with each other and change their own internal workings in response. Neural activity involves transmission of information via electrochemical events; in contrast, endocrine activity involves transmission of information via hormone transport to target tissues. Indirect cell communication paths: autocrine regulation: diffusion through extracellular fluid, paracrine regulation: diffusion through extracellular fluid, classical endocrine regulation: transported in blood, neurocrine regulation: transported in blood, classical neural regulation: diffuses across synapse. The target tissues for steroids do not have receptors for them on the membrane surface, because steroids are soluble in the lipid bilayer. Chemical messengers 6 classes: their structure will determine; The communication path taken to reach target cell. Their mode of action / interaction with the cell and receptors: 6 classes: lipids. Lipophilic cannot be stored in vesicles (endocrine path)

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