BIO 1140 Lecture Notes - Lecture 9: Mitophagy, Phosphatidylserine, Apaf1
26 Mar 2018
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February 12th 2018: limitations on atp generation in eukaryotes, entry of e from glycolysis into mitochondria, use of mitochondrial proton gradient for transport, oxidative phosphorylation is regulated by supply of adp. Mitochondria: generate atp, neurotransmitter metabolism, apoptosis, ammonia detoxifation, heme synthesis, cholesterol metabolism, fat and carbohydrate, pyrimidine biosynthesis, coded for 3000 by genes, generate free radicals, estrogen + testosterone synthesis rna/dna synthesis. Healthy: electrons supply energy to pump protons, protons accumulate, gradient drives atp production. If one mitochondria undergoes this process what happens to the cell: nothing. The other 9 mitochondria can reproduce by binary fission to fix the production of atp that has been lost. You have several protein surrounding the mitochondria waiting to attack it and label it as a dud and that it has to go. Therefore you have to get rid of the cell. Ligase are enzymes that stick different kinds of proteins together.
