BIO 3147 Lecture Notes - Lecture 12: Epiblast, Teratoma, Nuclear Transfer
Document Summary
Two daughter cells, one turns back to stem cell, other cell lacks something and turns to differentiated cell. Some stem cell pop will turn into differentiating pop. Progenitor can arguably self renew but are limited, should have kinda arrow. "stemminess", most stemmy at the left, no stemmy at differentiate. In current model note --> can go back up = dedifferentiation. Eg cancer --> can dedifferentiate to stem cell like function to keep dividing. Embryonic stem cells are of the embryonic epiblast. Trophoblast is higher, totipotent, blastocyst is totipotent too. Stem cells - the future: an introduction to ips cells. Add four factors and then can be reprogrammed. Some debate on whether embryo harvested vs reprogrammed are equal in stemminess. Example - somatic cell nuclear transfer for therapeutic use. Culture cells that you need and stick them back in you. Get cells --> fix the defect --> throw them back into bone marrow. Teratoma - cancer of all different cell types.
