BCH 3170 Lecture Notes - Lecture 16: Histone H3, Transcription Factor Ii H, Nucleosome
2 Mar 2016
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Document Summary
Control of gene expression in eukaryotes: regulatory proteins. Key feature of this complex is that it has no affinity for dna, it just connects all these things together. It interacts with the polymerase at the ctd level and the machinery. Transcription in the context of the eukaryotic domain. First step is to open the dna, here are two mechanisms to get from chromatin structure to the other. Atp-dependent chromatin remodeling complexes: non-covalent modification of the chromatin structure. Histones acetyltransferases: covalent modification of the chromatin structure. One aspect of the chromatin is that it has plasticity, it can be remodeled, not a fixed structure. The chromatin-remodeling complex does temporary remodeling, which is to give other proteins access to the dna, for repair, transcription, replication etc. Need a regulator to attract the chromatin remodeling complex. This complex shows up, uses atp to open the promoter, which is now accessible to dna pol, and now you have transcription.
