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Lecture

Membrane receptor signalling systems 2.docx

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Department
Biology
Course
BIO1140
Professor
A L L
Semester
Fall

Description
Cell to Cell SignallingMembrane receptor signalling systemsoReceptors that are present in the cell membranehave transmembrane domain that links them to the cell membraneoExtracellularoIntracellulardomain that activated the cell responseoSince these receptors are in the cell membrane they respond to signals in the extracellular environment signal doesnt have to cross the membraneoThey bind to the receptor at the ligand binding domain which is specific for a type of signalling moleculea stress hormone can only interact with a receptor for a stress hormoneoWatersoluble charged etc interact oBinds to receptor and causes it to undergo a conformation changeLigandgated channelsoExamples of ion channelschannel proteins that allow molecules to pass thorough them going down the diffusion gradientoWe are looking at ones that open or close in response to something binding to themoHave to have a ligandbinding site they are receptors and channelsoExskeletal muscle activation by acetylcholineActivated by signalling molecules released by nervesSkeletal musclesNerve releases a signalling molecules ND THE bind to a ligand binding domain on the channel protein which allows it to open or closeWhen acetylcholine binds to its ligand binding domain causes the channel to open which allows ions to pass through it and activates the muscle
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