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Lecture

Microtubules.docx

10 Pages
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Department
Biology
Course Code
BIO1140
Professor
A L L

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Description
FilamentsMicrotubulesohollow tubular structure of diameteraround 25 nmostraw like structure that has cell membrane drapped over itotwo basic typescytoplasmicvery dynamic constantly being broken down and built upaxonemalvery stable in cilia and flagellaofound in all eukaryotic cellsstructureoa heterodimer is used as the building block alphabeta tubulindimer is made of alpha and beta tubulins alpha on the bottom beta on the topeach binds a nucleotideGTPGTP binding siteWithin the globular structure of the proteinWhen you link together alpha and beta the GTP is protecteddoes not get hydrolyzedGTP bound to beta tubulins can be hydrolyzed to GDPProtofilamentstructural polarity end beta tubulin
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